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An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody
The structural and functional significance of somatic insertions and deletions in antibody chains is unclear. Here, we demonstrate that a naturally occurring three-amino-acid insertion within the influenza virus-specific human monoclonal antibody 2D1 heavy-chain variable region reconfigures the anti...
Autores principales: | Krause, Jens C., Ekiert, Damian C., Tumpey, Terrence M., Smith, Patricia B., Wilson, Ian A., Crowe, James E. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Society of Microbiology
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037006/ https://www.ncbi.nlm.nih.gov/pubmed/21304166 http://dx.doi.org/10.1128/mBio.00345-10 |
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