Investigating the Potential Role of Genetic and Epigenetic Variation of DNA Methyltransferase Genes in Hyperplastic Polyposis Syndrome

BACKGROUND: Hyperplastic Polyposis Syndrome (HPS) is a condition associated with multiple serrated polyps, and an increased risk of colorectal cancer (CRC). At least half of CRCs arising in HPS show a CpG island methylator phenotype (CIMP), potentially linked to aberrant DNA methyltransferase (DNMT)...

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Detalles Bibliográficos
Autores principales: Drini, Musa, Wong, Nicholas C., Scott, Hamish S., Craig, Jeffrey M., Dobrovic, Alexander, Hewitt, Chelsee A., Dow, Christofer, Young, Joanne P., Jenkins, Mark A., Saffery, Richard, Macrae, Finlay A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037390/
https://www.ncbi.nlm.nih.gov/pubmed/21347319
http://dx.doi.org/10.1371/journal.pone.0016831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037390/
https://www.ncbi.nlm.nih.gov/pubmed/21347319
http://dx.doi.org/10.1371/journal.pone.0016831

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