The ε3 and ε4 Alleles of Human APOE Differentially Affect Tau Phosphorylation in Hyperinsulinemic and Pioglitazone Treated Mice

BACKGROUND: Impaired insulin signalling is increasingly thought to contribute to Alzheimer's disease (AD). The ε4 isoform of the APOE gene is the greatest genetic risk factor for sporadic, late onset AD, and is also associated with risk for type 2 diabetes mellitus (T2DM). Neuropathological stu...

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Detalles Bibliográficos
Autores principales: To, Alvina W. M., Ribe, Elena M., Chuang, Tsu Tshen, Schroeder, Joern E., Lovestone, Simon
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037394/
https://www.ncbi.nlm.nih.gov/pubmed/21347323
http://dx.doi.org/10.1371/journal.pone.0016991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037394/
https://www.ncbi.nlm.nih.gov/pubmed/21347323
http://dx.doi.org/10.1371/journal.pone.0016991

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