Srf1 Is a Novel Regulator of Phospholipase D Activity and Is Essential to Buffer the Toxic Effects of C16:0 Platelet Activating Factor

During Alzheimer's Disease, sustained exposure to amyloid-β(42) oligomers perturbs metabolism of ether-linked glycerophospholipids defined by a saturated 16 carbon chain at the sn-1 position. The intraneuronal accumulation of 1-O-hexadecyl-2-acetyl-sn-glycerophosphocholine (C16:0 PAF), but not...

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Detalles Bibliográficos
Autores principales: Kennedy, Michael A., Kabbani, Nazir, Lambert, Jean-Philippe, Swayne, Leigh Anne, Ahmed, Fida, Figeys, Daniel, Bennett, Steffany A. L., Bryan, Jennnifer, Baetz, Kristin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037409/
https://www.ncbi.nlm.nih.gov/pubmed/21347278
http://dx.doi.org/10.1371/journal.pgen.1001299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037409/
https://www.ncbi.nlm.nih.gov/pubmed/21347278
http://dx.doi.org/10.1371/journal.pgen.1001299

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