Cellular pharmacology of multi- and duplex drugsconsisting of ethynylcytidine and 5-fluoro-2′-deoxyuridine

Prodrugs can have the advantage over parent drugs in increased activation and cellular uptake. The multidrug ETC-L-FdUrd and the duplex drug ETC-FdUrd are composed of two different monophosphate-nucleosides, 5-fluoro-2′deoxyuridine (FdUrd) and ethynylcytidine (ETC), coupled via a glycerolipid or pho...

Descripción completa

Detalles Bibliográficos
Autores principales: Bijnsdorp, Irene V., Schwendener, Reto A., Schott, Herbert, Fichtner, Iduna, Smid, Kees, Laan, Adrie C., Schott, Sarah, Losekoot, Nienke, Honeywell, Richard J., Peters, Godefridus J.
Formato: Texto
Lenguaje:English
Publicado: Springer US 2009
Materias:
Preclinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037477/
https://www.ncbi.nlm.nih.gov/pubmed/19957099
http://dx.doi.org/10.1007/s10637-009-9353-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037477/
https://www.ncbi.nlm.nih.gov/pubmed/19957099
http://dx.doi.org/10.1007/s10637-009-9353-2

Ejemplares similares