Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria

Bafilomycin A1 (Baf) induces an elevation of cytosolic Ca(2+) and acidification in neuronal cells via inhibition of the V-ATPase. Also, Baf uncouples mitochondria in differentiated PC12 ((d)PC12), (d)SH-SY5Y cells and cerebellar granule neurons, and markedly elevates their respiration. This respirat...

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Detalles Bibliográficos
Autores principales: Zhdanov, Alexander V., Dmitriev, Ruslan I., Papkovsky, Dmitri B.
Formato: Texto
Lenguaje:English
Publicado: SP Birkhäuser Verlag Basel 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037485/
https://www.ncbi.nlm.nih.gov/pubmed/20820851
http://dx.doi.org/10.1007/s00018-010-0502-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037485/
https://www.ncbi.nlm.nih.gov/pubmed/20820851
http://dx.doi.org/10.1007/s00018-010-0502-8

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