Visualization of cell-to-cell transmission of mutant huntingtin oligomers

We developed a new cell model for the visualization of toxic huntingtin oligomers in living cells. Huntingtin exon 1 (25Q or 103Q) was fused to non-fluorescent halves of the Venus protein. When huntingtin dimerizes inside the cells, Venus becomes functionally reconstituted and emits fluorescence. Ol...

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Detalles Bibliográficos
Autores principales: Herrera, Federico, Tenreiro, Sandra, Miller-Fleming, Leonor, Outeiro, Tiago Fleming
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Huntington Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037516/
https://www.ncbi.nlm.nih.gov/pubmed/21331289
http://dx.doi.org/10.1371/currents.RRN1210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037516/
https://www.ncbi.nlm.nih.gov/pubmed/21331289
http://dx.doi.org/10.1371/currents.RRN1210

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