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Folding, Quality Control, and Secretion of Pancreatic Ribonuclease in Live Cells

Although bovine pancreatic RNase is one of the best characterized proteins in respect to structure and in vitro refolding, little is known about its synthesis and maturation in the endoplasmic reticulum (ER) of live cells. We expressed the RNase in live cells and analyzed its folding, quality contro...

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Detalles Bibliográficos
Autores principales: Geiger, Roger, Gautschi, Matthias, Thor, Friederike, Hayer, Arnold, Helenius, Ari
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037694/
https://www.ncbi.nlm.nih.gov/pubmed/21156800
http://dx.doi.org/10.1074/jbc.M110.171694