Interplay between Kinase Domain Autophosphorylation and F-Actin Binding Domain in Regulating Imatinib Sensitivity and Nuclear Import of BCR-ABL

BACKGROUND: The constitutively activated BCR-ABL tyrosine kinase of chronic myeloid leukemia (CML) is localized exclusively to the cytoplasm despite the three nuclear localization signals (NLS) in the ABL portion of this fusion protein. The NLS function of BCR-ABL is re-activated by a kinase inhibit...

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Detalles Bibliográficos
Autores principales: Preyer, Martin, Vigneri, Paolo, Wang, Jean Y. J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037956/
https://www.ncbi.nlm.nih.gov/pubmed/21347248
http://dx.doi.org/10.1371/journal.pone.0017020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037956/
https://www.ncbi.nlm.nih.gov/pubmed/21347248
http://dx.doi.org/10.1371/journal.pone.0017020

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