Does Phenytoin Improve the Healing of Gastrointestinal Fistulas?

Pancreatic fistulas are among the most devastating complications after pancreatic surgery. Their subsequent development can be lethal. We report two cases of pancreatic fistulas treated with phenytoin. Fistula tract healing consists of several processes, including cell migration and the formation of...

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Autores principales: Jaber, Saed, Rihy, Zuhair, Joseph, Rafaeil, Al-Khayat, Mohammad
Formato: Texto
Lenguaje:English
Publicado: S. Karger AG 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037995/
https://www.ncbi.nlm.nih.gov/pubmed/21326859
http://dx.doi.org/10.1159/000322938
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author Jaber, Saed
Rihy, Zuhair
Joseph, Rafaeil
Al-Khayat, Mohammad
author_facet Jaber, Saed
Rihy, Zuhair
Joseph, Rafaeil
Al-Khayat, Mohammad
author_sort Jaber, Saed
collection PubMed
description Pancreatic fistulas are among the most devastating complications after pancreatic surgery. Their subsequent development can be lethal. We report two cases of pancreatic fistulas treated with phenytoin. Fistula tract healing consists of several processes, including cell migration and the formation of a new extracellular matrix. Multiple studies have shown that phenytoin can promote wound healing and induce faster fibrosis. We postulate that such a positive effect can be used to enhance fibrosis of the pancreatic fistula tract. We treated two patients who had developed high-output pancreatic fistulas after pancreatic surgery. The first underwent hand-assisted laparoscopic pancreatic necrosectomy and developed two high-output pancreatic fistulas and a colocutaneous fistula. The second occurred post Whipple surgery. Both were given oral phenytoin after failure to respond to other measures. In conclusion, oral phenytoin may have a positive effect in the treatment of fistulas. Prospective studies are needed to indicate this possible effect of phenytoin on fistula healing.
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spelling pubmed-30379952011-02-15 Does Phenytoin Improve the Healing of Gastrointestinal Fistulas? Jaber, Saed Rihy, Zuhair Joseph, Rafaeil Al-Khayat, Mohammad Case Rep Gastroenterol Published: January 2011 Pancreatic fistulas are among the most devastating complications after pancreatic surgery. Their subsequent development can be lethal. We report two cases of pancreatic fistulas treated with phenytoin. Fistula tract healing consists of several processes, including cell migration and the formation of a new extracellular matrix. Multiple studies have shown that phenytoin can promote wound healing and induce faster fibrosis. We postulate that such a positive effect can be used to enhance fibrosis of the pancreatic fistula tract. We treated two patients who had developed high-output pancreatic fistulas after pancreatic surgery. The first underwent hand-assisted laparoscopic pancreatic necrosectomy and developed two high-output pancreatic fistulas and a colocutaneous fistula. The second occurred post Whipple surgery. Both were given oral phenytoin after failure to respond to other measures. In conclusion, oral phenytoin may have a positive effect in the treatment of fistulas. Prospective studies are needed to indicate this possible effect of phenytoin on fistula healing. S. Karger AG 2011-01-14 /pmc/articles/PMC3037995/ /pubmed/21326859 http://dx.doi.org/10.1159/000322938 Text en Copyright © 2011 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published: January 2011
Jaber, Saed
Rihy, Zuhair
Joseph, Rafaeil
Al-Khayat, Mohammad
Does Phenytoin Improve the Healing of Gastrointestinal Fistulas?
title Does Phenytoin Improve the Healing of Gastrointestinal Fistulas?
title_full Does Phenytoin Improve the Healing of Gastrointestinal Fistulas?
title_fullStr Does Phenytoin Improve the Healing of Gastrointestinal Fistulas?
title_full_unstemmed Does Phenytoin Improve the Healing of Gastrointestinal Fistulas?
title_short Does Phenytoin Improve the Healing of Gastrointestinal Fistulas?
title_sort does phenytoin improve the healing of gastrointestinal fistulas?
topic Published: January 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037995/
https://www.ncbi.nlm.nih.gov/pubmed/21326859
http://dx.doi.org/10.1159/000322938
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