In Silico Quantitative Structure-Activity Relationship Studies on P-gp Modulators of Tetrahydroisoquinoline-Ethyl-Phenylamine Series

BACKGROUND: Multidrug resistance (MDR) is a major obstacle in cancer chemotherapy. The drug efflux by a transport protein is the main reason for MDR. In humans, MDR mainly occurs when the ATP-binding cassette (ABC) family of proteins is overexpressed simultaneously. P-glycoprotein (P-gp) is most com...

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Detalles Bibliográficos
Autores principales: Gadhe, Changdev G, Madhavan, Thirumurthy, Kothandan, Gugan, Cho, Seung Joo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038138/
https://www.ncbi.nlm.nih.gov/pubmed/21269449
http://dx.doi.org/10.1186/1472-6807-11-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038138/
https://www.ncbi.nlm.nih.gov/pubmed/21269449
http://dx.doi.org/10.1186/1472-6807-11-5

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