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The Pathogenesis of Alzheimer's Disease: A Reevaluation of the “Amyloid Cascade Hypothesis”
The most influential theory to explain the pathogenesis of Alzheimer's disease (AD) has been the “Amyloid Cascade Hypothesis” (ACH) first formulated in 1992. The ACH proposes that the deposition of β-amyloid (Aβ) is the initial pathological event in AD leading to the formation of senile plaques...
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| Formato: | Texto |
| Lenguaje: | English |
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SAGE-Hindawi Access to Research
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038555/ https://www.ncbi.nlm.nih.gov/pubmed/21331369 http://dx.doi.org/10.4061/2011/630865 |