Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN

By limiting phosphotidylinositol 3,4,5-triphosphate (PIP(3)) levels, tumor suppressor PTEN not only controls cell growth but also maintains cell polarity required for cytokinesis and chemotaxis. To identify the critical targets of PIP(3) that link it to the cytoskeleton, we deleted secondary genes t...

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Detalles Bibliográficos
Autores principales: Tang, Ming, Iijima, Miho, Kamimura, Yoichiro, Chen, Lingfeng, Long, Yu, Devreotes, Peter
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038642/
https://www.ncbi.nlm.nih.gov/pubmed/21169559
http://dx.doi.org/10.1091/mbc.E10-06-0522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038642/
https://www.ncbi.nlm.nih.gov/pubmed/21169559
http://dx.doi.org/10.1091/mbc.E10-06-0522

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