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Cell Surface Binding and Internalization of Aβ Modulated by Degree of Aggregation

The amyloid peptides, Aβ40 and Aβ42, are generated through endoproteolytic cleavage of the amyloid precursor protein. Here we have developed a model to investigate the interaction of living cells with various forms of aggregated Aβ40/42. After incubation at endosomal pH 6, we observed a variety of A...

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Detalles Bibliográficos
Autores principales: Bateman, David A., Chakrabartty, Avijit
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038693/
https://www.ncbi.nlm.nih.gov/pubmed/21331340
http://dx.doi.org/10.4061/2011/962352