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The G(1 )phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification

Because centrosome amplification generates aneuploidy and since centrosome amplification is ubiquitous in human tumors, a strong case is made for centrosome amplification being a major force in tumor biogenesis. Various evidence showing that oncogenes and altered tumor suppressors lead to centrosome...

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Detalles Bibliográficos
Autores principales: Harrison, Mary K, Adon, Arsene M, Saavedra, Harold I
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038874/
https://www.ncbi.nlm.nih.gov/pubmed/21272329
http://dx.doi.org/10.1186/1747-1028-6-2