The cGMP-Dependent Protein Kinase II Is an Inhibitory Modulator of the Hyperpolarization-Activated HCN2 Channel

Opening of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels is facilitated by direct binding of cyclic nucleotides to a cyclic nucleotide-binding domain (CNBD) in the C-terminus. Here, we show for the first time that in the HCN2 channel cGMP can also exert an inhibitory effect on g...

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Detalles Bibliográficos
Autores principales: Hammelmann, Verena, Zong, Xiangang, Hofmann, Franz, Michalakis, Stylianos, Biel, Martin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038938/
https://www.ncbi.nlm.nih.gov/pubmed/21347269
http://dx.doi.org/10.1371/journal.pone.0017078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038938/
https://www.ncbi.nlm.nih.gov/pubmed/21347269
http://dx.doi.org/10.1371/journal.pone.0017078

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