A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus

BACKGROUND: The major hurdle in the treatment of Human Immunodeficiency virus type 1 (HIV-1) includes the development of drug resistance-associated mutations in the target regions of the virus. Since reverse transcriptase (RT) is essential for HIV-1 replication, several nucleoside analogues have bee...

Descripción completa

Detalles Bibliográficos
Autores principales: Chunduri, HimaBindu, Rimland, David, Nurpeisov, Viktoria, Crumpacker, Clyde S, Sharma, Prem L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038945/
https://www.ncbi.nlm.nih.gov/pubmed/21255423
http://dx.doi.org/10.1186/1743-422X-8-33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038945/
https://www.ncbi.nlm.nih.gov/pubmed/21255423
http://dx.doi.org/10.1186/1743-422X-8-33

Ejemplares similares