Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria

The first synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl- alanyl) has been achieved using a solution-phase technique via coupling of dipeptide segments Boc-l-Pro-l-Leu-OH and l-Ala-l-Ile-OMe. Deprotection of the linear tetrapeptide unit and its subsequent cyclization...

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Detalles Bibliográficos
Autores principales: Dahiya, Rajiv, Gautam, Hemendra
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039471/
https://www.ncbi.nlm.nih.gov/pubmed/21339947
http://dx.doi.org/10.3390/md9010071
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author Dahiya, Rajiv
Gautam, Hemendra
author_facet Dahiya, Rajiv
Gautam, Hemendra
author_sort Dahiya, Rajiv
collection PubMed
description The first synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl- alanyl) has been achieved using a solution-phase technique via coupling of dipeptide segments Boc-l-Pro-l-Leu-OH and l-Ala-l-Ile-OMe. Deprotection of the linear tetrapeptide unit and its subsequent cyclization gave a cyclopeptide, identical in all aspects to the naturally occurring compound. Bioactivity results indicated the antifungal and antihelmintic potential of the synthesized peptide against pathogenic dermatophytes and earthworms.
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spelling pubmed-30394712011-02-18 Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria Dahiya, Rajiv Gautam, Hemendra Mar Drugs Article The first synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl- alanyl) has been achieved using a solution-phase technique via coupling of dipeptide segments Boc-l-Pro-l-Leu-OH and l-Ala-l-Ile-OMe. Deprotection of the linear tetrapeptide unit and its subsequent cyclization gave a cyclopeptide, identical in all aspects to the naturally occurring compound. Bioactivity results indicated the antifungal and antihelmintic potential of the synthesized peptide against pathogenic dermatophytes and earthworms. Molecular Diversity Preservation International 2010-12-30 /pmc/articles/PMC3039471/ /pubmed/21339947 http://dx.doi.org/10.3390/md9010071 Text en © 2011 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Dahiya, Rajiv
Gautam, Hemendra
Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria
title Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria
title_full Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria
title_fullStr Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria
title_full_unstemmed Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria
title_short Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria
title_sort toward the synthesis and biological screening of a cyclotetrapeptide from marine bacteria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039471/
https://www.ncbi.nlm.nih.gov/pubmed/21339947
http://dx.doi.org/10.3390/md9010071
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AT gautamhemendra towardthesynthesisandbiologicalscreeningofacyclotetrapeptidefrommarinebacteria

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