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Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells

BACKGROUND: Dendritic cells (DCs) are antigen-presenting immune cells that interact with T cells and have been widely studied for vaccine applications. To achieve this, DCs can be manipulated by lentiviral vectors (LVs) to express antigens to stimulate the desired antigen-specific T cell response, w...

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Detalles Bibliográficos
Autores principales: Tai, April, Froelich, Steven, Joo, Kye-Il, Wang, Pin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039557/
https://www.ncbi.nlm.nih.gov/pubmed/21276219
http://dx.doi.org/10.1186/1754-1611-5-1