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Issues associated with the use of phosphospecific antibodies to localise active and inactive pools of GSK-3 in cells
ABSTRACT: BACKGROUND: Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine (Ser/Thr) kinase comprising two isoforms, GSK-3α and GSK-3β. Both enzymes are similarly inactivated by serine phosphorylation (GSK-3α at Ser21 and GSK-3β at Ser9) and activated by tyrosine phosphory...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039639/ https://www.ncbi.nlm.nih.gov/pubmed/21261990 http://dx.doi.org/10.1186/1745-6150-6-4 |