CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity

Loss of CXCL12, a leukocyte localizing cue, from abluminal surfaces of the blood–brain barrier occurs in multiple sclerosis (MS) lesions. However, the mechanisms and consequences of reduced abluminal CXCL12 abundance remain unclear. Here, we show that activation of CXCR7, which scavenges CXCL12, is...

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Detalles Bibliográficos
Autores principales: Cruz-Orengo, Lillian, Holman, David W., Dorsey, Denise, Zhou, Liang, Zhang, Penglie, Wright, Melissa, McCandless, Erin E., Patel, Jigisha R., Luker, Gary D., Littman, Dan R., Russell, John H., Klein, Robyn S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039853/
https://www.ncbi.nlm.nih.gov/pubmed/21300915
http://dx.doi.org/10.1084/jem.20102010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039853/
https://www.ncbi.nlm.nih.gov/pubmed/21300915
http://dx.doi.org/10.1084/jem.20102010

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