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The Impact of the C-Terminal Domain on the Interaction of Human DNA Topoisomerase II α and β with DNA
BACKGROUND: Type II DNA topoisomerases are essential, ubiquitous enzymes that act to relieve topological problems arising in DNA from normal cellular activity. Their mechanism of action involves the ATP-dependent transport of one DNA duplex through a transient break in a second DNA duplex; metal ion...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040172/ https://www.ncbi.nlm.nih.gov/pubmed/21358820 http://dx.doi.org/10.1371/journal.pone.0014693 |