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Prolonged Mechanical Ventilation Induces Cell Cycle Arrest in Newborn Rat Lung

RATIONALE: The molecular mechanism(s) by which mechanical ventilation disrupts alveolar development, a hallmark of bronchopulmonary dysplasia, is unknown. OBJECTIVE: To determine the effect of 24 h of mechanical ventilation on lung cell cycle regulators, cell proliferation and alveolar formation in...

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Detalles Bibliográficos
Autores principales: Kroon, Andreas A., Wang, Jinxia, Kavanagh, Brian, Huang, Zhen, Kuliszewski, Maciej, van Goudoever, Johannes B., Post, Martin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040197/
https://www.ncbi.nlm.nih.gov/pubmed/21359218
http://dx.doi.org/10.1371/journal.pone.0016910