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Molecular Dynamics Simulations of Forced Unbending of Integrin α(V)β(3)
Integrins may undergo large conformational changes during activation, but the dynamic processes and pathways remain poorly understood. We used molecular dynamics to simulate forced unbending of a complete integrin α(V)β(3) ectodomain in both unliganded and liganded forms. Pulling the head of the int...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040657/ https://www.ncbi.nlm.nih.gov/pubmed/21379327 http://dx.doi.org/10.1371/journal.pcbi.1001086 |