A Dynamical Systems Model for Combinatorial Cancer Therapy Enhances Oncolytic Adenovirus Efficacy by MEK-Inhibition

Oncolytic adenoviruses, such as ONYX-015, have been tested in clinical trials for currently untreatable tumors, but have yet to demonstrate adequate therapeutic efficacy. The extent to which viruses infect targeted cells determines the efficacy of this approach but many tumors down-regulate the Coxs...

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Detalles Bibliográficos
Autores principales: Bagheri, Neda, Shiina, Marisa, Lauffenburger, Douglas A., Korn, W. Michael
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040662/
https://www.ncbi.nlm.nih.gov/pubmed/21379332
http://dx.doi.org/10.1371/journal.pcbi.1001085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040662/
https://www.ncbi.nlm.nih.gov/pubmed/21379332
http://dx.doi.org/10.1371/journal.pcbi.1001085

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