Efficient Wnt mediated intestinal hyperproliferation requires the cyclin D2-CDK4/6 complex

Inactivation of the gene encoding the adenomatous polyposis coli (APC) tumour suppressor protein is recognized as the key early event in the development of colorectal cancers (CRC). Apc loss leads to nuclear localization of beta-catenin and constitutive activity of the beta-catenin-Tcf4 transcriptio...

Descripción completa

Detalles Bibliográficos
Autores principales: Myant, Kevin, Sansom, Owen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040687/
https://www.ncbi.nlm.nih.gov/pubmed/21288356
http://dx.doi.org/10.1186/1747-1028-6-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040687/
https://www.ncbi.nlm.nih.gov/pubmed/21288356
http://dx.doi.org/10.1186/1747-1028-6-3

Ejemplares similares