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Efficient Wnt mediated intestinal hyperproliferation requires the cyclin D2-CDK4/6 complex
Inactivation of the gene encoding the adenomatous polyposis coli (APC) tumour suppressor protein is recognized as the key early event in the development of colorectal cancers (CRC). Apc loss leads to nuclear localization of beta-catenin and constitutive activity of the beta-catenin-Tcf4 transcriptio...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040687/ https://www.ncbi.nlm.nih.gov/pubmed/21288356 http://dx.doi.org/10.1186/1747-1028-6-3 |