SUMO-1 regulates the conformational dynamics of Thymine-DNA Glycosylase regulatory domain and competes with its DNA binding activity

BACKGROUND: The human thymine-DNA glycosylase (TDG) plays a dual role in base excision repair of G:U/T mismatches and in transcription. Regulation of TDG activity by SUMO-1 conjugation was shown to act on both functions. Furthermore, TDG can interact with SUMO-1 in a non-covalent manner. RESULTS: Us...

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Detalles Bibliográficos
Autores principales: Smet-Nocca, Caroline, Wieruszeski, Jean-Michel, Léger, Hélène, Eilebrecht, Sebastian, Benecke, Arndt
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040724/
https://www.ncbi.nlm.nih.gov/pubmed/21284855
http://dx.doi.org/10.1186/1471-2091-12-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040724/
https://www.ncbi.nlm.nih.gov/pubmed/21284855
http://dx.doi.org/10.1186/1471-2091-12-4

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