Intracerebroventricular Leptin Infusion Improves Glucose Homeostasis in Lean Type 2 Diabetic MKR Mice via Hepatic Vagal and Non-Vagal Mechanisms

MKR mice, lacking insulin-like growth factor 1 receptor (IGF-1R) signaling in skeletal muscle, are lean yet hyperlipidemic, hyperinsulinemic, and hyperglycemic, with severe insulin resistance and elevated hepatic and skeletal muscle levels of triglycerides. We have previously shown that chronic peri...

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Detalles Bibliográficos
Autores principales: Li, Xiaosong, Wu, Xhiping, Camacho, Raul, Schwartz, Gary J., LeRoith, Derek
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040739/
https://www.ncbi.nlm.nih.gov/pubmed/21379576
http://dx.doi.org/10.1371/journal.pone.0017058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040739/
https://www.ncbi.nlm.nih.gov/pubmed/21379576
http://dx.doi.org/10.1371/journal.pone.0017058

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