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Functional Mutation of Multiple Solvent-Exposed Loops in the Ecballium elaterium Trypsin Inhibitor-II Cystine Knot Miniprotein

BACKGROUND: The Ecballium elaterium trypsin inhibitor (EETI-II), a 28-amino acid member of the knottin family of peptides, contains three interwoven disulfide bonds that form multiple solvent-exposed loops. Previously, the trypsin binding loop of EETI-II has been engineered to confer binding to seve...

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Detalles Bibliográficos
Autores principales: Kimura, Richard H., Jones, Douglas S., Jiang, Lei, Miao, Zheng, Cheng, Zhen, Cochran, Jennifer R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041754/
https://www.ncbi.nlm.nih.gov/pubmed/21364742
http://dx.doi.org/10.1371/journal.pone.0016112