Impaired desensitization of a human polymorphic α(2B)-adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells

BACKGROUND: α(2)-adrenergic receptors (ARs) mediate many cellular actions of epinephrine and norepinephrine and inhibit their secretion from adrenal chromaffin cells. Like many other G-protein coupled receptors (GPCRs), they undergo agonist-dependent phopshorylation and desensitization by GPCR Kinas...

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Detalles Bibliográficos
Autores principales: Nguyen, Kristy, Kassimatis, Theodoros, Lymperopoulos, Anastasios
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041786/
https://www.ncbi.nlm.nih.gov/pubmed/21299895
http://dx.doi.org/10.1186/1478-811X-9-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041786/
https://www.ncbi.nlm.nih.gov/pubmed/21299895
http://dx.doi.org/10.1186/1478-811X-9-5

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