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Impaired desensitization of a human polymorphic α(2B)-adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells
BACKGROUND: α(2)-adrenergic receptors (ARs) mediate many cellular actions of epinephrine and norepinephrine and inhibit their secretion from adrenal chromaffin cells. Like many other G-protein coupled receptors (GPCRs), they undergo agonist-dependent phopshorylation and desensitization by GPCR Kinas...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041786/ https://www.ncbi.nlm.nih.gov/pubmed/21299895 http://dx.doi.org/10.1186/1478-811X-9-5 |