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PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway

BACKGROUND: Coronaviruses such as severe acute respiratory syndrome (SARS) coronavirus (SCoV) and mouse hepatitis virus A59 (MHV-A59) have evolved strategies to disable the innate immune system for productive replication and spread of infection. We have previously shown that papain-like protease dom...

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Detalles Bibliográficos
Autores principales: Wang, Gang, Chen, Gang, Zheng, Dahai, Cheng, Genhong, Tang, Hong
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041802/
https://www.ncbi.nlm.nih.gov/pubmed/21364999
http://dx.doi.org/10.1371/journal.pone.0017192