O(6)-Methylguanine-DNA Methyltransferase (MGMT) mRNA Expression Predicts Outcome in Malignant Glioma Independent of MGMT Promoter Methylation

BACKGROUND: We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with concomitant and adjuvant temozolomide or temozolomide al...

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Detalles Bibliográficos
Autores principales: Kreth, Simone, Thon, Niklas, Eigenbrod, Sabina, Lutz, Juergen, Ledderose, Carola, Egensperger, Rupert, Tonn, Joerg C., Kretzschmar, Hans A., Hinske, Ludwig C., Kreth, Friedrich W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041820/
https://www.ncbi.nlm.nih.gov/pubmed/21365007
http://dx.doi.org/10.1371/journal.pone.0017156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041820/
https://www.ncbi.nlm.nih.gov/pubmed/21365007
http://dx.doi.org/10.1371/journal.pone.0017156

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