Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases

BACKGROUND AND PURPOSE: Fenretinide (4-HPR) is a retinoic acid analogue, currently used in clinical trials in oncology. Metabolism of 4-HPR is of particular interest due to production of the active metabolite 4′-oxo 4-HPR and the clinical challenge of obtaining consistent 4-HPR plasma concentrations...

Descripción completa

Detalles Bibliográficos
Autores principales: Illingworth, NA, Boddy, AV, Daly, AK, Veal, GJ
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042207/
https://www.ncbi.nlm.nih.gov/pubmed/21054342
http://dx.doi.org/10.1111/j.1476-5381.2010.01104.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042207/
https://www.ncbi.nlm.nih.gov/pubmed/21054342
http://dx.doi.org/10.1111/j.1476-5381.2010.01104.x

Ejemplares similares