Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway

BACKGROUND: Thrombolytic therapy with tissue plasminogen activator (tPA) benefits patients with acute ischemic stroke. However, tPA increases the risk for intracerebral bleeding and enhances post-ischemic neuronal injury if administered 3-4 hours after stroke. Therefore, combination therapies with t...

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Detalles Bibliográficos
Autores principales: Guo, Huang, Barrett, Theresa M, Zhong, Zhihui, Fernández, José A, Griffin, John H, Freeman, Robert S, Zlokovic, Berislav V
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042387/
https://www.ncbi.nlm.nih.gov/pubmed/21291561
http://dx.doi.org/10.1186/1750-1326-6-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042387/
https://www.ncbi.nlm.nih.gov/pubmed/21291561
http://dx.doi.org/10.1186/1750-1326-6-13

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