ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function

Activating the amyloid cascade by inhibiting the Aβ-degrading enzyme neprilysin in targeted replacement mice, which express either apoE4 or apoE3, results in the specific accumulation of oligomerized Aβ42 in hippocampal CA1 neurons of the apoE4 mice. We presently investigated the extent to which the...

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Detalles Bibliográficos
Autores principales: Zepa, Lia, Frenkel, Moran, Belinson, Haim, Kariv-Inbal, Zehavit, Kayed, Rakez, Masliah, Eliezer, Michaelson, Daniel M.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042644/
https://www.ncbi.nlm.nih.gov/pubmed/21350674
http://dx.doi.org/10.4061/2011/792070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042644/
https://www.ncbi.nlm.nih.gov/pubmed/21350674
http://dx.doi.org/10.4061/2011/792070

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