Hypoxia Triggers Major Metabolic Changes in AML Cells without Altering Indomethacin-Induced TCA Cycle Deregulation

[Image: see text] Our previous studies have shown that the nonsteroidal anti-inflammatory drug indomethacin exhibits antileukemic activity in vitro and can inhibit the aldo-keto reductase AKR1C3, which we identified as a novel target in acute myeloid leukemia. However, the antileukemic actions of in...

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Detalles Bibliográficos
Autores principales: Lodi, Alessia, Tiziani, Stefano, Khanim, Farhat L., Drayson, Mark T., Günther, Ulrich L., Bunce, Christopher M., Viant, Mark R.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042854/
https://www.ncbi.nlm.nih.gov/pubmed/20886892
http://dx.doi.org/10.1021/cb900300j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042854/
https://www.ncbi.nlm.nih.gov/pubmed/20886892
http://dx.doi.org/10.1021/cb900300j

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