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Accurate statistics for local sequence alignment with position-dependent scoring by rare-event sampling
BACKGROUND: Molecular database search tools need statistical models to assess the significance for the resulting hits. In the classical approach one asks the question how probable a certain score is observed by pure chance. Asymptotic theories for such questions are available for two random i.i.d. s...
Autores principales: | Wolfsheimer, Stefan, Herms, Inke, Rahmann, Sven, Hartmann, Alexander K |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042914/ https://www.ncbi.nlm.nih.gov/pubmed/21291566 http://dx.doi.org/10.1186/1471-2105-12-47 |
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