Uncoordinated Transcription and Compromised Muscle Function in the Lmna-Null Mouse Model of Emery-Dreifuss Muscular Dystrophy

LMNA encodes both lamin A and C: major components of the nuclear lamina. Mutations in LMNA underlie a range of tissue-specific degenerative diseases, including those that affect skeletal muscle, such as autosomal-Emery-Dreifuss muscular dystrophy (A-EDMD) and limb girdle muscular dystrophy 1B. Here,...

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Detalles Bibliográficos
Autores principales: Gnocchi, Viola F., Scharner, Juergen, Huang, Zhe, Brady, Ken, Lee, Jaclyn S., White, Robert B., Morgan, Jennifer E., Sun, Yin-Biao, Ellis, Juliet A., Zammit, Peter S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043058/
https://www.ncbi.nlm.nih.gov/pubmed/21364987
http://dx.doi.org/10.1371/journal.pone.0016651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043058/
https://www.ncbi.nlm.nih.gov/pubmed/21364987
http://dx.doi.org/10.1371/journal.pone.0016651

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