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An Effective Assessment of Simvastatin-Induced Toxicity with NMR-Based Metabonomics Approach
BACKGROUND: Simvastatin, which is used to control elevated cholesterol levels, is one of the most widely prescribed drugs. However, a daily excessive dose can induce drug-toxicity, especially in muscle and liver. Current markers for toxicity reflect mostly the late stages of tissue damage; thus, mor...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043067/ https://www.ncbi.nlm.nih.gov/pubmed/21364936 http://dx.doi.org/10.1371/journal.pone.0016641 |