The frontotemporal dementia mutation R406W blocks tau’s interaction with the membrane in an annexin A2–dependent manner

Changes of the microtubule-associated protein tau are central in Alzheimer’s disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17). However, the functional consequence of the FTDP-17 tau mutation R406W, which causes a tauopathy clinically resembling AD, is not...

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Detalles Bibliográficos
Autores principales: Gauthier-Kemper, Anne, Weissmann, Carina, Golovyashkina, Nataliya, Sebö-Lemke, Zsofia, Drewes, Gerard, Gerke, Volker, Heinisch, Jürgen J., Brandt, Roland
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044115/
https://www.ncbi.nlm.nih.gov/pubmed/21339331
http://dx.doi.org/10.1083/jcb.201007161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044115/
https://www.ncbi.nlm.nih.gov/pubmed/21339331
http://dx.doi.org/10.1083/jcb.201007161

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