Cargando…
Tem1 localization to the spindle pole bodies is essential for mitotic exit and impairs spindle checkpoint function
The mitotic exit network (MEN) is a signaling cascade that triggers inactivation of the mitotic cyclin-dependent kinases and exit from mitosis. The GTPase Tem1 localizes on the spindle pole bodies (SPBs) and initiates MEN signaling. Tem1 activity is inhibited until anaphase by Bfa1-Bub2. These prote...
| Autores principales: | , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2011
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044116/ https://www.ncbi.nlm.nih.gov/pubmed/21321099 http://dx.doi.org/10.1083/jcb.201007044 |