AID Induces Double-Strand Breaks at Immunoglobulin Switch Regions and c-MYC Causing Chromosomal Translocations in Yeast THO Mutants

Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by Activation Induced Cytidine Deaminase (AID), triggering class switch recombination (CSR), as well as translocations with c-MYC responsible for Burkitt's lymphomas. In Sacchar...

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Detalles Bibliográficos
Autores principales: Ruiz, José F., Gómez-González, Belén, Aguilera, Andrés
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044682/
https://www.ncbi.nlm.nih.gov/pubmed/21383964
http://dx.doi.org/10.1371/journal.pgen.1002009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044682/
https://www.ncbi.nlm.nih.gov/pubmed/21383964
http://dx.doi.org/10.1371/journal.pgen.1002009

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