Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour Suppressor

BACKGROUND: Dot1L, a histone methyltransferase that targets histone H3 lysine 79 (H3K79), has been implicated in gene regulation and the DNA damage response although its functions in these processes remain poorly defined. METHODOLOGY/PRINCIPAL FINDINGS: Using the chicken DT40 model system, we genera...

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Detalles Bibliográficos
Autores principales: FitzGerald, Jennifer, Moureau, Sylvie, Drogaris, Paul, O'Connell, Enda, Abshiru, Nebiyu, Verreault, Alain, Thibault, Pierre, Grenon, Muriel, Lowndes, Noel F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044716/
https://www.ncbi.nlm.nih.gov/pubmed/21383990
http://dx.doi.org/10.1371/journal.pone.0014714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044716/
https://www.ncbi.nlm.nih.gov/pubmed/21383990
http://dx.doi.org/10.1371/journal.pone.0014714

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