p16(INK4a) Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms

Although caloric restriction (CR) has been shown to increase lifespan in various animal models, the mechanisms underlying this phenomenon have not yet been revealed. We developed an in vitro system to mimic CR by reducing glucose concentration in cell growth medium which excludes metabolic factors a...

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Detalles Bibliográficos
Autores principales: Li, Yuanyuan, Tollefsbol, Trygve O.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044759/
https://www.ncbi.nlm.nih.gov/pubmed/21390332
http://dx.doi.org/10.1371/journal.pone.0017421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044759/
https://www.ncbi.nlm.nih.gov/pubmed/21390332
http://dx.doi.org/10.1371/journal.pone.0017421

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