Transcriptional Regulation by Asf1: NEW MECHANISTIC INSIGHTS FROM STUDIES OF THE DNA DAMAGE RESPONSE TO REPLICATION STRESS

Asf1 is a conserved histone H3/H4 chaperone. We find that Asf1 in budding yeast promotes an essential cellular response to replication stress caused by the ribonucleotide reductase inhibitor hydroxyurea. That is, Asf1 stimulates derepression of DNA damage response (DDR) genes during the S phase. Der...

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Detalles Bibliográficos
Autores principales: Minard, Laura V., Williams, Jessica S., Walker, Amelia C., Schultz, Michael C.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Gene Regulation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044965/
https://www.ncbi.nlm.nih.gov/pubmed/21190944
http://dx.doi.org/10.1074/jbc.M110.193813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044965/
https://www.ncbi.nlm.nih.gov/pubmed/21190944
http://dx.doi.org/10.1074/jbc.M110.193813

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