Maternal High Fat Diet Is Associated with Decreased Plasma n–3 Fatty Acids and Fetal Hepatic Apoptosis in Nonhuman Primates

To begin to understand the contributions of maternal obesity and over-nutrition to human development and the early origins of obesity, we utilized a non-human primate model to investigate the effects of maternal high-fat feeding and obesity on breast milk, maternal and fetal plasma fatty acid compos...

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Autores principales: Grant, Wilmon F., Gillingham, Melanie B., Batra, Ayesha K., Fewkes, Natasha M., Comstock, Sarah M., Takahashi, Diana, Braun, Theodore P., Grove, Kevin L., Friedman, Jacob E., Marks, Daniel L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045408/
https://www.ncbi.nlm.nih.gov/pubmed/21364873
http://dx.doi.org/10.1371/journal.pone.0017261
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author Grant, Wilmon F.
Gillingham, Melanie B.
Batra, Ayesha K.
Fewkes, Natasha M.
Comstock, Sarah M.
Takahashi, Diana
Braun, Theodore P.
Grove, Kevin L.
Friedman, Jacob E.
Marks, Daniel L.
author_facet Grant, Wilmon F.
Gillingham, Melanie B.
Batra, Ayesha K.
Fewkes, Natasha M.
Comstock, Sarah M.
Takahashi, Diana
Braun, Theodore P.
Grove, Kevin L.
Friedman, Jacob E.
Marks, Daniel L.
author_sort Grant, Wilmon F.
collection PubMed
description To begin to understand the contributions of maternal obesity and over-nutrition to human development and the early origins of obesity, we utilized a non-human primate model to investigate the effects of maternal high-fat feeding and obesity on breast milk, maternal and fetal plasma fatty acid composition and fetal hepatic development. While the high-fat diet (HFD) contained equivalent levels of n-3 fatty acids (FA's) and higher levels of n-6 FA's than the control diet (CTR), we found significant decreases in docosahexaenoic acid (DHA) and total n-3 FA's in HFD maternal and fetal plasma. Furthermore, the HFD fetal plasma n-6∶n-3 ratio was elevated and was significantly correlated to the maternal plasma n-6∶n-3 ratio and maternal hyperinsulinemia. Hepatic apoptosis was also increased in the HFD fetal liver. Switching HFD females to a CTR diet during a subsequent pregnancy normalized fetal DHA, n-3 FA's and fetal hepatic apoptosis to CTR levels. Breast milk from HFD dams contained lower levels of eicosopentanoic acid (EPA) and DHA and lower levels of total protein than CTR breast milk. This study links chronic maternal consumption of a HFD with fetal hepatic apoptosis and suggests that a potentially pathological maternal fatty acid milieu is replicated in the developing fetal circulation in the nonhuman primate.
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spelling pubmed-30454082011-03-01 Maternal High Fat Diet Is Associated with Decreased Plasma n–3 Fatty Acids and Fetal Hepatic Apoptosis in Nonhuman Primates Grant, Wilmon F. Gillingham, Melanie B. Batra, Ayesha K. Fewkes, Natasha M. Comstock, Sarah M. Takahashi, Diana Braun, Theodore P. Grove, Kevin L. Friedman, Jacob E. Marks, Daniel L. PLoS One Research Article To begin to understand the contributions of maternal obesity and over-nutrition to human development and the early origins of obesity, we utilized a non-human primate model to investigate the effects of maternal high-fat feeding and obesity on breast milk, maternal and fetal plasma fatty acid composition and fetal hepatic development. While the high-fat diet (HFD) contained equivalent levels of n-3 fatty acids (FA's) and higher levels of n-6 FA's than the control diet (CTR), we found significant decreases in docosahexaenoic acid (DHA) and total n-3 FA's in HFD maternal and fetal plasma. Furthermore, the HFD fetal plasma n-6∶n-3 ratio was elevated and was significantly correlated to the maternal plasma n-6∶n-3 ratio and maternal hyperinsulinemia. Hepatic apoptosis was also increased in the HFD fetal liver. Switching HFD females to a CTR diet during a subsequent pregnancy normalized fetal DHA, n-3 FA's and fetal hepatic apoptosis to CTR levels. Breast milk from HFD dams contained lower levels of eicosopentanoic acid (EPA) and DHA and lower levels of total protein than CTR breast milk. This study links chronic maternal consumption of a HFD with fetal hepatic apoptosis and suggests that a potentially pathological maternal fatty acid milieu is replicated in the developing fetal circulation in the nonhuman primate. Public Library of Science 2011-02-25 /pmc/articles/PMC3045408/ /pubmed/21364873 http://dx.doi.org/10.1371/journal.pone.0017261 Text en Grant et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Grant, Wilmon F.
Gillingham, Melanie B.
Batra, Ayesha K.
Fewkes, Natasha M.
Comstock, Sarah M.
Takahashi, Diana
Braun, Theodore P.
Grove, Kevin L.
Friedman, Jacob E.
Marks, Daniel L.
Maternal High Fat Diet Is Associated with Decreased Plasma n–3 Fatty Acids and Fetal Hepatic Apoptosis in Nonhuman Primates
title Maternal High Fat Diet Is Associated with Decreased Plasma n–3 Fatty Acids and Fetal Hepatic Apoptosis in Nonhuman Primates
title_full Maternal High Fat Diet Is Associated with Decreased Plasma n–3 Fatty Acids and Fetal Hepatic Apoptosis in Nonhuman Primates
title_fullStr Maternal High Fat Diet Is Associated with Decreased Plasma n–3 Fatty Acids and Fetal Hepatic Apoptosis in Nonhuman Primates
title_full_unstemmed Maternal High Fat Diet Is Associated with Decreased Plasma n–3 Fatty Acids and Fetal Hepatic Apoptosis in Nonhuman Primates
title_short Maternal High Fat Diet Is Associated with Decreased Plasma n–3 Fatty Acids and Fetal Hepatic Apoptosis in Nonhuman Primates
title_sort maternal high fat diet is associated with decreased plasma n–3 fatty acids and fetal hepatic apoptosis in nonhuman primates
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045408/
https://www.ncbi.nlm.nih.gov/pubmed/21364873
http://dx.doi.org/10.1371/journal.pone.0017261
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