Cargando…

Upstream open reading frames: Molecular switches in (patho)physiology

Conserved upstream open reading frames (uORFs) are found within many eukaryotic transcripts and are known to regulate protein translation. Evidence from genetic and bioinformatic studies implicates disturbed uORF-mediated translational control in the etiology of human diseases. A genetic mouse model...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wethmar, Klaus, Smink, Jeske J, Leutz, Achim
Formato:	Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2010
Materias:	Prospects & Overviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045505/ https://www.ncbi.nlm.nih.gov/pubmed/20726009 http://dx.doi.org/10.1002/bies.201000037

Ejemplares similares

Comprehensive translational control of tyrosine kinase expression by upstream open reading frames
por: Wethmar, K, et al.
Publicado: (2016)

The cost of circadian desynchrony: Evidence, insights and open questions
por: West, Alexander C., et al.
Publicado: (2015)

Shaping mitotic chromosomes: From classical concepts to molecular mechanisms
por: Kschonsak, Marc, et al.
Publicado: (2015)

Heritable L1 Retrotransposition Events During Development: Understanding Their Origins: Examination of heritable, endogenous L1 retrotransposition in mice opens up exciting new questions and research directions
por: Richardson, Sandra R., et al.
Publicado: (2018)

Stress-induced mutation via DNA breaks in Escherichia coli: A molecular mechanism with implications for evolution and medicine
por: Rosenberg, Susan M, et al.
Publicado: (2012)

Co‐transcriptional mRNP formation is coordinated within a molecular mRNP packaging station in S. cerevisiae
por: Meinel, Dominik M., et al.
Publicado: (2015)

Somatic Functional Deletions of Upstream Open Reading Frame-Associated Initiation and Termination Codons in Human Cancer
por: Jürgens, Lara, et al.
Publicado: (2021)

Mitochondria and the culture of the Borg
por: Braschi, Emelie, et al.
Publicado: (2010)

Orthology prediction methods: A quality assessment using curated protein families
por: Trachana, Kalliopi, et al.
Publicado: (2011)

Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models
por: Huijbers, Ivo J, et al.
Publicado: (2011)

Scientific discovery as a combinatorial optimisation problem: How best to navigate the landscape of possible experiments?
por: Kell, Douglas B
Publicado: (2012)

Long non-coding RNA modifies chromatin: Epigenetic silencing by long non-coding RNAs
por: Saxena, Alka, et al.
Publicado: (2011)

From transporter to transceptor: Signaling from transporters provokes re-evaluation of complex trafficking and regulatory controls: Endocytic internalization and intracellular trafficking of nutrient transceptors may, at least in part, be governed by their signaling function
por: Kriel, Johan, et al.
Publicado: (2011)

Function and evolution of sex determination mechanisms, genes and pathways in insects
por: Gempe, Tanja, et al.
Publicado: (2011)

Innovation in biological microscopy: Current status and future directions
por: Swedlow, Jason R
Publicado: (2012)

Identifying the genomic determinants of aging and longevity in human population studies: Progress and challenges
por: Deelen, Joris, et al.
Publicado: (2013)

Population transcriptomics with single-cell resolution: A new field made possible by microfluidics: A technology for high throughput transcript counting and data-driven definition of cell types
por: Plessy, Charles, et al.
Publicado: (2013)

Current status of drug screening and disease modelling in human pluripotent stem cells
por: Rajamohan, Divya, et al.
Publicado: (2013)

The emerging biology of muscle stem cells: Implications for cell-based therapies
por: Bentzinger, C Florian, et al.
Publicado: (2013)

Circadian rhythms and mood: Opportunities for multi-level analyses in genomics and neuroscience
por: Li, Jun Z
Publicado: (2014)

Transfer and functional consequences of dietary microRNAs in vertebrates: Concepts in search of corroboration: Negative results challenge the hypothesis that dietary xenomiRs cross the gut and regulate genes in ingesting vertebrates, but important questions persist
por: Witwer, Kenneth W, et al.
Publicado: (2014)

Variable escape from X-chromosome inactivation: Identifying factors that tip the scales towards expression
por: Peeters, Samantha B, et al.
Publicado: (2014)

Keeping your armour intact: How HIV-1 evades detection by the innate immune system
por: Maelfait, Jonathan, et al.
Publicado: (2014)

Microtubule dynamic instability: A new model with coupled GTP hydrolysis and multistep catastrophe
por: Bowne-Anderson, Hugo, et al.
Publicado: (2013)

Pausing for thought: Disrupting the early transcription elongation checkpoint leads to developmental defects and tumourigenesis
por: Jennings, Barbara H
Publicado: (2013)

Multi-step down-regulation of the secretory pathway in mitosis: A fresh perspective on protein trafficking
por: Yeong, Foong May
Publicado: (2013)

Segmental folding of chromosomes: A basis for structural and regulatory chromosomal neighborhoods?
por: Nora, Elphège P, et al.
Publicado: (2013)

A frontier in the understanding of synaptic plasticity: Solving the structure of the postsynaptic density
por: Gold, Matthew G
Publicado: (2012)

Transcriptional mechanisms of cell fate decisions revealed by single cell expression profiling
por: Moignard, Victoria, et al.
Publicado: (2014)

Functional interpretation of non-coding sequence variation: Concepts and challenges
por: Paul, Dirk S, et al.
Publicado: (2014)

Modeling and simulation of biological systems from image data
por: Sbalzarini, Ivo F
Publicado: (2013)

Sources of dynamic variability in NF-κB signal transduction: A mechanistic model
por: Mothes, Janina, et al.
Publicado: (2015)

Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification
por: Iyer, Lakshminarayan M., et al.
Publicado: (2015)

Variation is function: Are single cell differences functionally important?: Testing the hypothesis that single cell variation is required for aggregate function
por: Dueck, Hannah, et al.
Publicado: (2015)

Mouse models of colorectal cancer as preclinical models
por: McIntyre, Rebecca E., et al.
Publicado: (2015)

Fetal microchimerism and maternal health: A review and evolutionary analysis of cooperation and conflict beyond the womb
por: Boddy, Amy M., et al.
Publicado: (2015)

Luminescent sensing and imaging of oxygen: Fierce competition to the Clark electrode
por: Wolfbeis, Otto S.
Publicado: (2015)

Introns and gene expression: Cellular constraints, transcriptional regulation, and evolutionary consequences
por: Heyn, Patricia, et al.
Publicado: (2015)

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research
por: Hoitzing, Hanne, et al.
Publicado: (2015)

Wax, sex and the origin of species: Dual roles of insect cuticular hydrocarbons in adaptation and mating
por: Chung, Henry, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_6pf73lseh6fnlvo9dl6natvn82