Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools

The mechanisms by which imbalanced dNTPs induce mutations have been well characterized within a test tube, but not in vivo. We have examined mechanisms by which dNTP imbalances induce genome instability in strains of Saccharomyces cerevisiae with different amino acid substitutions in Rnr1, the large...

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Detalles Bibliográficos
Autores principales: Kumar, Dinesh, Abdulovic, Amy L., Viberg, Jörgen, Nilsson, Anna Karin, Kunkel, Thomas A., Chabes, Andrei
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045583/
https://www.ncbi.nlm.nih.gov/pubmed/20961955
http://dx.doi.org/10.1093/nar/gkq829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045583/
https://www.ncbi.nlm.nih.gov/pubmed/20961955
http://dx.doi.org/10.1093/nar/gkq829

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